Flavopiridol (Alvocidib) hydrochloride
Flavopiridol Hydrochloride
CAS: 131740-09-5
Molecular Formula: C21H21Cl2NO5
Flavopiridol (Alvocidib) hydrochloride - Names and Identifiers
Flavopiridol (Alvocidib) hydrochloride - Physico-chemical Properties
| Molecular Formula | C21H21Cl2NO5 |
| Molar Mass | 438.3 |
| Melting Point | 169.5-170°C |
| Specific Rotation(α) | 24D -1.73 to -3.9° |
| Solubility | H2O: ~2mg/mL |
| Appearance | powder |
| Color | white to light brown |
| pKa | 5.68 ± 0.06(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month |
| In vitro study | Flavopiridol was originally found to inhibit the activity of epidermal growth factor receptor and protein kinase A, with IC50 values of 21 μm and 122 μm, respectively. Flavopiridol was later shown to inhibit cell proliferation at a variety of physiologically relevant concentrations (IC50=66 nM), tumor cell lines were tested in 60 human cancer cell lines developed by the National Cancer Institute in the United States. Flavopiridol induces G1 phase arrest and inhibits CDK2 and CDK4 in human breast cancer cells in a time-and concentration-dependent manner. Flavopiridol short-time treatment (~ 12 h) induced apoptosis in hematopoietic cell lines including SUDHL4,SUDHL6(B cell line),Jurkat and MOLT4(T cell line) and HL60 (myeloid cell line). In clonogenic experiments, Flavopiridol exhibited high cytotoxicity in 23 human tumor models with an average IC70 of 8 ng/mL. A recent study showed that Flavopiridol induces AKT-Ser473 phosphorylation in a human glioma T98G cell line. |
| In vivo study | At the maximum tolerated dose of 10 mg/kg/day on days 1-4 and 7-11, Flavopiridol showed tumor regression of PRXF1337 and tumor stasis of PRXF1369 for 4 weeks. After 5 consecutive days of intravenous (IV) or intraperitoneal injection with 7.5 mg/kg Flavopiridol, tumors in 11 out of 12 subcutaneous (SC) human HL-60 transplanted mice completely regressed, transplanted mice were disease-free for several months after one course of Flavopiridol treatment. After intravenous injection of Flavopiridol (7.5 mg/kg) into SUDHL-4 subcutaneous lymphoma model mice, the tumors of the model mice were mostly (2/8) or completely (4/8) regressed, two remaining animals were disease-free for more than 60 days. Overall growth was delayed by 73.2. |
Flavopiridol (Alvocidib) hydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
| RTECS | DJ2978830 |
Flavopiridol (Alvocidib) hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.282 ml | 11.408 ml | 22.815 ml |
| 5 mM | 0.456 ml | 2.282 ml | 4.563 ml |
| 10 mM | 0.228 ml | 1.141 ml | 2.282 ml |
| 5 mM | 0.046 ml | 0.228 ml | 0.456 ml |
Last Update：2024-01-02 23:10:35
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CAS: 131740-09-5
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Product Name: Flavopiridol Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 131740-09-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 131740-09-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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